\documentclass[a4paper]{article}
\usepackage{comment}
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\usepackage[box,completemulti,noshuffle]{automultiplechoice}    
\begin{document}


\onecopy{10} {    

%%% beginning of the test sheet header:    
\noindent{\bf Quiz 5  \hfill \today}



\vspace*{.5cm}
%\begin{minipage}{.4\linewidth}\centering\large\bf Quiz\\ Oct. 2, 2015\end{minipage}
%\namefield{\fbox{    
 %               \begin{minipage}{.5\linewidth}
  %                Firstname and lastname:
%
 %                 \vspace*{.5cm}\dotfill
  %                \vspace*{1mm}
   %             \end{minipage}
    %     }}

{\setlength{\parindent}{0pt}\hspace*{\fill}\AMCcode{etu}{8}\hspace*{\fill}
\begin{minipage}[b]{6.5cm}
$\longleftarrow{}$\hspace{0pt plus 1cm} please encode the LAST 8 digits of your student number in the boxes to the left,
and write your first and last names below.

\vspace{3ex}
\hfill\namefield{\fbox{    
    \begin{minipage}{.9\linewidth}
      Firstname and lastname:
      
      \vspace*{.5cm}\dotfill
      
      \vspace*{.5cm}\dotfill
      \vspace*{1mm}
    \end{minipage}
  }}\hfill\vspace{5ex}\end{minipage}\hspace*{\fill}
}



\begin{center}\em
		Choose the one alternative that best completes the statement or answers the question.

  %No documents allowed. The use of electronic calculators is forbidden.


  %Questions using the sign \multiSymbole{} may have
  %zero, one or several correct answers.  Other questions have a single correct answer.

  %Negative points may be attributed to \emph{very
   % bad} answers.
\end{center}
\vspace{1ex}

%%% end of the header

\begin{question}{q01}
$\ldots$ of prokaryotic genomes are now available in public databases.
\begin{choiceshoriz}
\wrongchoice{Hundreds}
\wrongchoice{Millions}
\wrongchoice{Dozens}      
\correctchoice{Thousands}
\end{choiceshoriz}
\end{question}

\begin{question}{q02}
Microarrays can be used to $\ldots$
\begin{choices}
\wrongchoice{detect unwanted food additives or substitutes.}
\correctchoice{detect pathogens, analyze global gene expression, and detect unwanted food additives or substitutes.}
\wrongchoice{detect pathogens.}
\wrongchoice{analyze global gene expression.}
\end{choices}
\end{question}

\begin{question}{q03}
Transcriptome analysis is useful in relation to genome analysis because$\ldots$
\begin{choices}
\wrongchoice{it is NOT dependent on nucleic acid sequencing technology.}
\correctchoice{it analyzes RNA, thus it reveals which genes are expressed under different conditions.}
\wrongchoice{it reveals interactions between molecules and, thus, provides more information than genome analysis.}
\wrongchoice{it results in amino acid sequence and is, thus, easier to analyze.}
\end{choices}
\end{question}

\begin{question}{q04}
The entire complement of RNA produced under a given set of conditions is called a(n)$\ldots$
\begin{choiceshoriz}
\wrongchoice{genome.}
\correctchoice{transcriptome.}
\wrongchoice{proteome.}
\wrongchoice{array.}
\end{choiceshoriz}
\end{question}

\begin{question}{q05}
The very first DNA sequencing technology called the Sanger method relies on$\ldots$
\begin{choices}
\wrongchoice{nanopore technology that separates DNA molecul}es based on charge differences.
\wrongchoice{the release of protons whenever a new nucleoti}de is added to a growing strand of DNA.
\wrongchoice{nuclear magnetic resonance (NMR) analysis.}
\correctchoice{the incorporation of dideoxynucleotides that terminate chain extension during DNA synthesis.}
\end{choices}
\end{question}

\begin{question}{q06}
Within Archaea and Bacteria, one megabasepairs of DNA encode about $\ldots$ open reading frames.
\begin{choiceshoriz}
\wrongchoice{10,000}
\wrongchoice{10}
\correctchoice{1,000}
\wrongchoice{100}
\end{choiceshoriz}
\end{question}


\begin{question}{q07}
The advantage(s) of second-generation DNA sequencing compared to the Sanger method are the result of$\ldots$
\begin{choices}
\correctchoice{miniaturization of reaction size and increased computer power.}
\wrongchoice{increased computing power.}
\wrongchoice{increased length of DNA sequences obtained.}
\wrongchoice{miniaturization of reaction size.}
\end{choices}
\end{question}


\begin{question}{q08}
You want to know whether the virulence genes present in Bordetella pertussis are evolutionarily related to genes in the less pathogenic species B. bronchiseptica or if the virulence genes were acquired via horizontal gene transfer. What characteristic(s) would you compare to answer this question?      									
\begin{choices}
\wrongchoice{ribosomal binding site and intron sequence}
\wrongchoice{number of genes in the pan genome}
\wrongchoice{genome size and number of introns}
\correctchoice{percentage of GC content and codon usage}
\end{choices}
\end{question}

\begin{question}{q09}
Linking an ORF with a specific function is an example of gene
\begin{choiceshoriz}
\wrongchoice{codon bias.}
\wrongchoice{assembly.}
\wrongchoice{expression.}
\correctchoice{annotation.}
\end{choiceshoriz}
\end{question}

\begin{question}{q10}
Chromosomal islands contain clusters of genes for       			
\begin{choices}
\wrongchoice{catabolic and anabolic reactions.}
\wrongchoice{antibiotic resistance.}
\wrongchoice{DNA repair and replication.}
\correctchoice{virulence, biodegradation of pollutants, and symbiotic relationships.}
\end{choices}
\end{question}

\begin{question}{q11}
The first genome sequenced was that of a       				
\begin{choiceshoriz}
\wrongchoice{bacterium.}
\wrongchoice{eukaryote.}
\correctchoice{virus.}
\wrongchoice{archaeon.}
\end{choiceshoriz}
\end{question}

\begin{question}{q12}
Genome assembly relies on     							 
\begin{choices}
\wrongchoice{systems biology.}
\wrongchoice{accurate gene annotation.}
\wrongchoice{codon bias.}
\correctchoice{overlap of a large numbers of short sequences.}
\end{choices}
\end{question}

\begin{question}{q13}
The core genome of a prokaryotic species is the genomic content that is     	 
\begin{choices}
\wrongchoice{expressed under all environmental conditions.}
\correctchoice{shared between all other prokaryotes.}
\wrongchoice{shared between all strains of a species.}
\wrongchoice{unique compared to all other prokaryotes.}
\end{choices}
\end{question}

\begin{question}{q14}
Chloroplasm genome is usually smaller than mitochondria genome
\begin{choiceshoriz}
\wrongchoice{TRUE}
\correctchoice{FALSE}
\end{choiceshoriz}
\end{question}

\begin{question}{q15}
mitochondria genome is usually linear
\begin{choiceshoriz}
\wrongchoice{TRUE}
\correctchoice{FALSE}
\end{choiceshoriz}
\end{question}

\begin{question}{q16}
Human mitochondria genome size is $\ldots$
\begin{choices}
\wrongchoice{10 - 500 bp}
\correctchoice{10000 -25000 bp}
\wrongchoice{50000 - 500000 bp}
\wrongchoice{it is a single-stranded RNA of 17460 nt }
\end{choices}
\end{question}

\begin{question}{q17}
chloroplasts' genome encodes for unique enzyme called $\ldots$
\begin{choices}
\wrongchoice{actin }
\wrongchoice{DNA oxidase}
\correctchoice{Ribulose-1,5-bisphosphate carboxylase}
\wrongchoice{neurominizade }
\end{choices}
\end{question}

\begin{question}{q18}
new genes usually arise through the mechanism of $\ldots$
\begin{choiceshoriz}
\wrongchoice{remediation }
\wrongchoice{mutations}
\wrongchoice{sequencing}
\correctchoice{duplication}
\end{choiceshoriz}
\end{question}

\begin{question}{q19}
Two-dimensional SDS-PAGE electrophoresis followed by mass spectrometry is used to characterize
\begin{choiceshoriz}
\wrongchoice{genome}
\wrongchoice{transcriptome}
\correctchoice{ proteome}
\wrongchoice{metabolome}
\end{choiceshoriz}
\end{question}

\begin{question}{q20}
maximal genome size is found in $\ldots$
\begin{choiceshoriz}
\wrongchoice{T4 phage}
\correctchoice{Pine tree}
\wrongchoice{Homo neanderthalensis}
\wrongchoice{Homo sapience}
\end{choiceshoriz}
\end{question}

\clearpage
}   
\end{document}
